In order to better exploit the detection advantages of wind profile radar in upper layer, the detection data of ST wind profile radar during 2014-2017 from Huainan Climate and Environment Observatory (HCEO), Institute of Atmospheric Physics, Chinese Academy of Sciences, were used to evaluate the detection performance of ST wind profile radar under different detection mode combinations, and the influence of meteorological environment on detection performance was explored. On this basis, the applicability of detection mode combinations was discriminated in practical operations. The results show that ST wind profile radar can achieve different detection purposes by combining high or low modes with switching altitude. However, there are differences in detection performance under different combinations of mode. On the one hand, the detection performance of radar gradually decreases before the mode conversion and rapidly increases after the mode conversion, while it gradually decreases with height under the high mode. On the other hand, the detection performance of radar doesn’t change significantly in process of the conversion, while it gradually decreases after the high mode to a certain height. In addition, the reducing degree of detection performance gradually increases as the transition altitude approach in autumn and winter. The precipitation reduces the detection performance in lower and middle layers of troposphere. So, we select suitable mode combination based on the detection performance of radar to atmospheric boundary layer, troposphere and stratosphere.