Desertification has become a major threat to the global ecological environment, and the desertification monitoring is crucial for desertification prevention and control. Based on the Suomi/NPP (National Polar-orbiting Partnership) remote sensing data and the observation data of 8 meteorological stations during the vegetation growing season (from May to September) from 2014 to 2021 in the Qaidam Basin, the desertification difference index (DDI) was calculated by using NDVI-Albedo (Normalized Difference Vegetation Index-Albedo) feature space. Moreover, the natural discontinuity method, Sen+M-K trend analysis method, correlation analysis method, accuracy error matrix and transfer matrix analysis were also used to explore the spatial and temporal dynamic evolution of land desertification and the influence of meteorological factors to desertification in the Qaidam Basin from 2014 to 2020 during the vegetation growing season. The results are as follows: (1) The NDVI-Albedo feature space performs a high applicability in the Qaidam Basin (R2 greater than or equal to 0.65), with an overall classification accuracy of 79.38% and a Kappa coefficient of 0.62. (2) From 2014 to 2021, the degree of land desertification in the eastern and southern Qaidam Basin is lower than that in the western and central Qaidam Basin. Furthermore, DDI shows a significantly increase in some areas, especially in southern and eastern region with the increase rate of DDI over 0.01a-1. The total area of desertification land in the Qaidam Basin shows a decreasing trend with a rate of -1 173 km2·a-1. Additionally, a transforming characteristic occurs between different degrees desertification land that severe desertification lands transferred to mild desertification land. (3) Correlation analysis shows that precipitation and average relative humidity are significantly positively correlated with DDI (P<0.01), and correlation coefficients are 0.91 and 0.86, respectively, indicating that the water is the dominant factor affecting desertification in the Qaidam Basin.